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n South African Journal of Obstetrics and Gynaecology - Oestrogen supplementation in gamete intrafallopian transfer (GIFT) - a prospective randomised study

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Abstract

<I>Objective.</I> To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrafallopian transfer (GIFT). <br><I>Methods.</I> Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measures were biochemical pregnancy rate and clinical pregnancy rate. <br><I>Results.</I> The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the controlgroup (p = 0.096, 95% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p= 0.1988, 95% CI: 10.3 - 31.7%). <br><I>Conclusion.</I> Although the results of this study show no significant statistical difference, there is a clinical trend in favour of giving oestrogen support.

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/content/m_sajog/11/1/EJC65779
2005-02-01
2016-12-05
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