n South African Journal of Obstetrics and Gynaecology - Oestrogen supplementation in gamete intrafallopian transfer (GIFT) - a prospective randomised study
|Article Title||Oestrogen supplementation in gamete intrafallopian transfer (GIFT) - a prospective randomised study|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Journal of Obstetrics and Gynaecology|
|Author||A.P.H. De Decker, T.F. Kruger, T.I. Siebert, J.P. Van der Merwe and C.J. Lombard|
|Publication Date||Feb 2005|
|Pages||6 - 8|
<I>Objective.</I> To investigate the impact of oestrogen supplementation from the early luteal to the late proliferative phase on biochemical and ongoing pregnancy rates in gamete intrafallopian transfer (GIFT). <br><I>Methods.</I> Ninety-five patients were assigned to clomiphene citrate-human menopausal gonadotrophin (hMG)-induced GIFT cycles, with or without the use of oestrogen support (oral administration of estradiol valerate). The main outcome measures were biochemical pregnancy rate and clinical pregnancy rate. <br><I>Results.</I> The biochemical pregnancy rate was 38.09% in the oestrogen group v. 22.9% in the controlgroup (p = 0.096, 95% CI: 5.7 - 37.3%). The clinical pregnancy rate in the oestrogen supplementation group was 23.8% v. 14.58% in the control group (p= 0.1988, 95% CI: 10.3 - 31.7%). <br><I>Conclusion.</I> Although the results of this study show no significant statistical difference, there is a clinical trend in favour of giving oestrogen support.
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