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n South African Journal of Obstetrics and Gynaecology - The effect of sperm morphology and testicular spermatozoa on embryo quality : research article
Objective. To determine the correlation between sperm morphology groups (strict criteria) and testicular spermatozoa, and day 2 and 3 embryo quality in intracytoplasmic sperm injection (ICSI) and in vitro fertilisation (IVF) cases.
Methods. A retrospective study was done of 2 402 IVF and ICSI-fertilised embryos classified as goodquality embryos (GQEs) or poor-quality embryos (PQEs). Sperm morphology (strict criteria) was classified as teratozoospermia (P-pattern (< 5% normal); G-pattern (5 - 14% normal)), normozoospermia (N-pattern (> 14% normal)), and testicular spermatozoa (immature, only ICSI group).
Results. Sperm morphology (P, G, and N-patterns) and immature esticular sperm had no effect on day 2 or 3 embryo quality for ICSI (p = 0.82) and IVF-fertilised (p = 0.64) embryos. A significant increase in GQEs from day 2 to 3 in the P-pattern group (33 - 39%, p = 0.002) and testicular spermatozoa group (30 - 35%, p = 0.014) was found in ICSI cases.
Conclusion. Morphology of human spermatozoa according to Tygerberg's strict criteria and testicular spermatozoa had no predictive value for the outcome of day 2 and 3 embryo quality.
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