n South African Journal of Obstetrics and Gynaecology - A review of the incidence and survival of childhood and adolescent cancer and the effects of treatment on future fertility and endocrine development : review




Cancer is not uncommon in children. The reproductive system is an important site for late effects of cancer treatment, and normal pubertal development depends on an undamaged hypothalamic-pituitary-gonadal axis. Fertility compromise can occur due to chemotherapy, radiotherapy to the hypothalamic-pituitary-gonadal axis, or surgery. Cryopreservation techniques of germ cells are improving and may offer hope for fertility preservation.


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