n South African Journal of Obstetrics and Gynaecology - Misoprostol for cervical ripening at and near term - a comparative study

Volume 9, Issue 2
  • ISSN : 0038-2329
  • E-ISSN: 2078-5135



&lt;I&gt;Objective.&lt;/I&gt; To compare the safety and efficacy of misoprostol with that of dinoprostone for the induction of labour at term, or near term. <br><I>Design. &lt;/I&gt; Three hundred and ninety-six women with term pregnancies were randomised to receive either oral or vaginal misoprostol, or dinoprostone. Women who had had a p revious caesarean section (CS) or those with a malpre sentation or who were parity ³ 5, were excluded. The control group received dinoprostone 1 mg inserted in the posterior fornix and repeated 6-hourly to a maximum of three doses. The study group received either oral misoprostol 20 µg 2-hourly to a maximum of four doses (80 µg), or vaginal misoprostol 25 µg in the posterior fornix with a switch to the oral misoprostol regimen if there was no change in the Bishop's score or no palpable uterine contractions. &lt;br&gt;&lt;I&gt;Results.&lt;/I&gt; There was no significant difference in vaginal delivery rate within 24 hours between the groups (58.1% v. 58%, p = 0.633). There were no significant differences in CS rates between the groups; however, more CSs were performed for fetal distress in the misoprostol group than in the dinoprostone group (28% v. 25%). There was a significantly higher incidence of hyperstimulation in the vaginal misoprostol group (21.4%) than in the other two groups (oral misoprostol 16.5%, dinoprostone 8.9%) (p = 0.004). The incidence of meconium staining of liquor was comparable between the groups. &lt;br&gt;&lt;I&gt;Conclusions.&lt;/I&gt; In selected women, the efficacy of misoprostol for the induction of labour at term is similar to that of dinoprostone but misoprostol is associated with a higher incidence of hyperstimulation.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error