n South African Journal of Psychiatry - CINP 2005 Regional Meeting Cape Town, 20 - 22 April 2005 : abstracts

Volume 11, Issue 1
  • ISSN : 1608-9685
  • E-ISSN: 2078-6786
  • Author
  • Source : South African Journal of Psychiatry, Volume 11, Issue 1, Apr 2005, p. 25 - 36
  • Accreditation : Department of Higher Education and Training (DHET)
    SciELO SA
    The Sciences Citation Index of the Institute of Scientific Information (ISI)
    The Social Sciences Citation Index of the ISI



Extracted from text ... Psychiatry: Selected abstracts ANTIPSYCHOTICS ACROSS THE SPECTRUM: AN OVERVIEW OF THEIR MECHANISMS OF ACTION Anissa Abi-Dargham (Professor of Clinical Psychiatry and Radiology at Columbia University) Imaging studies in schizophrenia have shown an association between dopaminergic hyperactivity in the mesolimbic pathway and positive symptoms, and suggested dopaminergic hypoactivity in the mesocortical pathway underlying cognitive impairment and negative symptoms. In addition, studies of dopamine glutamate interactions have shown that dopaminergic alterations in schizophrenia may be secondary to a glutamatergic dysfunction. These data support a predominant and well established role for D2 antagonism in the treatment of schizophrenia, while providing new strategies for ..

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