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n South African Journal of Psychiatry - Deficient testosterone levels in men above 45 years with major depressive disorder - an age-matched case control study : article
Background. Symptoms of partial androgen deficiency in ageing men (PADAM) overlap considerably with those of major depressive disorder. The relationship between these conditions is complicated by the usual age-related decline in serum testosterone concentrations.
Objectives. To test the hypothesis that depressed men above 45 years of age have lower serum testosterone concentrations than age-matched controls.
Method. Serum testosterone fractions of 20 men above the age of 45 years suffering from a major depressive disorder were compared with those of 20 healthy men. An age-matched controlled design was used to account for the usual age-related decline in serum testosterone concentrations.
Results. Testosterone concentrations of men suffering from a major depressive disorder were statistically significantly lower than those of an age-matched control group without depression.
Conclusion. The role of testosterone deficiency in depressed men needs to be examined further in order for appropriate treatment options to be developed.
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