n SA Journal of Radiology - The enigma of reversible splenial lesions : case series




Focal reversible lesions of the splenium of the corpus callosum have been described in a number of clinical paradigms. Epilepsy and related conditions are the most commonly reported underlying clinical association. Sudden anti-epileptic therapy withdrawal or seizure activity may be presumed to be the predisposing cause. However, an individual susceptibility must also be considered. Although the exact mechanism producing this syndrome is not known, the MRI appearance and course in each of these clinically distinct causative entities is similar. The complete reversibility of the abnormality on follow-up studies is common to all, and many authors suggest that a conservative watchful approach is all that is required. We present here the findings in two patients with similar, completely reversible, splenial lesions.


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