n SA Journal of Radiology - Face of the giant panda sign in Wilson disease : signs

Volume 17, Issue 3
  • ISSN : 1027-202X
  • E-ISSN: 2078-6778



Wilson disease usually presents with neurological or hepatic manifestations. Magnetic resonance imaging (MRI) of the brain is most informative in diagnosing this disease, especially in patients with neurological features. High T2 signal intensity in the corpus striatum is the most commonly encountered MRI finding. The 'face of the giant panda' sign, seen on axial T2-weighted MRI, results from abnormal signal intensities in the midbrain. Though uncommon, the sign is regarded as the pathognomonic MRI sign of Wilson disease.

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