n SA Journal of Radiology - Can ulceration in carcinoma of the oesophagus be detected by 99mTc- sucralfate scan? : original article
|Article Title||Can ulceration in carcinoma of the oesophagus be detected by 99mTc- sucralfate scan? : original article|
|Journal||SA Journal of Radiology|
|Author||V. Sharma, S. Awasare, V. Rangrajan, H.H. Shimpi, U. Mahantshetty and P.S. Choudhary|
|Publication Date||Dec 2005|
|Pages||17 - 20|
<I>Objective.</I> To test: (i) the sensitivity and positive predictive value of tagged material in delineating ulcerations of the oesophagus in the pre- and post-treatment periods and at follow-up; and (ii) whether tagging could reduce the need for invasive endoscopic procedures in patients with carcinoma of the oesophagus. <br><I>Materials and methods.</I> Twenty-nine patients with carcinoma of the oesophagus selected for radiation therapy underwent the <sup>99m</sup>Tc sucralfate scintimaging prior to radiation therapy. Patients were asked to drink 10 ml suspension of 10 mci <sup>99m</sup>Tc sucralfate. The sequential images of the oesophagus were acquired at 2 minutes, 2 hours, 4 hours and 6 hours following ingestion. In some patients images were also acquired at 24 hours and at follow-up. The comparison was done with endoscopy as the gold standard. <br><I>Results and observations.</I> The overall positivity of the test was 83% at 4 hours (24 of 29 patients), 34% at 6 hours (10 of 29 patients) and 24% at 24 hours (7 of 29 patients). The sensitivity of the test was 85%, and the positive predictive value 50%. <br><I>Conclusion.</I> Due to low positive predictive value, this investigation cannot replace endoscopy to diagnose ulcerative disease in patients with carcinoma of the oesophagus.
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