n South African Journal of Surgery - Coagulation for the clinician : review article




Extracted from text ... Review Article SAJS 22 VOL 44, NO. 1, FEBRUARY 2006 SAJS Coagulation physiology The integrity of the circulation is maintained through the provision of a rapid, potent, but tightly localised coagulation response to vascular damage. There is, however, one extraordinary problem in the regulation of haemostasis - blood flows. Normal haemostasis is the ability of the haemostatic system to control activation of clot formation and clot lysis in order to prevent haemorrhage without causing thrombosis. It classically involves vasoconstriction, platelet adhesion and aggregation at the site of injury, leading to a plug formation. This is followed by fibrin formation consolidating ..


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