n South African Journal of Surgery - The role of Ki-67 in breast cancer : review

Volume 54, Issue 2
  • ISSN : 0038-2361
  • E-ISSN: 2078-5151



The proliferative marker, Ki-67, is a human nuclear antigen, and forms an integral part of cell division in both normal and malignant tissue. Since the hallmark of cancer is uncontrolled and relentless cell proliferation, the Ki-67 proliferative index is increasingly used to assess and manage breast cancer. The value of Ki-67 as a prognostic indicator, a guide to the selection of therapy, and a method of measuring response to ongoing treatment, is examined in this review.

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