n South African Journal of Sports Medicine - The effect of a professional cricket match schedule on selected immune parameters : original research article
|Article Title||The effect of a professional cricket match schedule on selected immune parameters : original research article|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Journal of Sports Medicine|
|Author||A.W. Williams, K.H. Myburgh and C. Smith|
|Publication Date||Jun 2004|
|Pages||22 - 27|
<I>Objective.</I> The impact of a professional cricket match schedule on white blood cell (WBC) distribution and lymphocyte activation (CD69 expression) was investigated. <br><I>Methods.</I> After a 3-month pre-season training period, physical and immune parameters were determined in 14 male cricketers before (B) and after (A) an intensive 5- week match schedule. <br><I>Results.</I> Exercise test results were unchanged from B to A. Total WBC counts were similar, but total lymphocyte and lymphocyte subpopulation counts decreased significantly. The CD4:CD8 ratio did not change. After <I>in vitro</I> stimulation, percentage CD4+CD69+ cells increased (B: 54.4 <u>+</u> 9.7%, A: 64.0 <u>+</u> 8.5%, <I>p</I> < 0.01), but absolute CD4+CD69+ cell counts did not change from B to A. In contrast, both the %CD8+CD69+ cells and absolute CD8+CD69+ cell count remained similar. <br><I>Conclusion.</I> A strenuous, interregional, professional cricket match schedule resulted in a decreased number of lymphocytes, but relatively increased <I>in vitro</I> reactivity of CD4+ cells, thus maintaining the absolute capacity of the CD4+ cells to become activated on stimulation. In cricketers who suffered upper respiratory tract symptoms during the match schedule (<I>N</I> = 7), none of the immune parameters investigated differed significantly from the others at B or A.
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