n South African Journal of Sports Medicine - Cyclooxygenase inhibitors and the exercise-induced stress response : original research article
|Article Title||Cyclooxygenase inhibitors and the exercise-induced stress response : original research article|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Journal of Sports Medicine|
|Author||N. Claassen, J. Snyman, A. Koorts, H. Nolte, B. Wagenaar, M. Kruger, P.J. Becker and M. Viljoen|
|Publication Date||Mar 2006|
|Pages||4 - 8|
<i>Objective.</i> This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. <br><i>Design.</i> Eight subjects (age 20.9 <u>+</u> 1.1 years, weight 70.4 <u>+</u> 3.9 kg, height 170.9 <u>+</u> 6.7 cm, body surface area 1.82 <u>+</u> 0.09 m<sup>2</sup>, body mass index 24.1 <u>+</u> 1.3 kg.m<sup>-2</sup>) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). <br><i>Results.</i> Mean post-exercise cortisol values were signifi-cantly higher than pre-exercise values with the subjects on placebo (<i>p</i> = 0.0365) and rofecoxib (<i>p</i> = 0.0208), but not on naproxen (<i>p</i> = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (<i>p</i> = 0.0153) and rofecoxib (<i>p</i> = 0.0424), but not on naproxen (<i>p</i> = 0.5444). <br><i>Conclusion.</i> The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise.
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