n South African Journal of Sports Medicine - Cyclooxygenase inhibitors and the exercise-induced stress response : original research article

Volume 18, Issue 1
  • ISSN : 1015-5163
  • E-ISSN: 2078-516X



&lt;i&gt;Objective.&lt;/i&gt; This study investigated the effects of single dosages of the non-steroidal anti-inflammatory drug (NSAID) naproxen, and of the coxib, rofecoxib, on the exercise-induced stress response. &lt;br&gt;&lt;i&gt;Design.&lt;/i&gt; Eight subjects (age 20.9 &lt;u&gt;+&lt;/u&gt; 1.1 years, weight 70.4 &lt;u&gt;+&lt;/u&gt; 3.9 kg, height 170.9 &lt;u&gt;+&lt;/u&gt; 6.7 cm, body surface area 1.82 <u>+</u> 0.09 m<sup>2</sup>, body mass index 24.1 &lt;u&gt;+&lt;/u&gt; 1.3 kg.m<sup>-2</sup>) took part in a double-blind, drug-placebo, cross-over design study. The experimental procedures were performed on 3 occasions on each volunteer, i.e. once on placebo, once on naproxen (single dose of 1 000 mg) and once on rofecoxib (single dose of 50 mg). &lt;br&gt;&lt;i&gt;Results.&lt;/i&gt; Mean post-exercise cortisol values were signifi-cantly higher than pre-exercise values with the subjects on placebo (&lt;i&gt;p&lt;/i&gt; = 0.0365) and rofecoxib (&lt;i&gt;p&lt;/i&gt; = 0.0208), but not on naproxen (&lt;i&gt;p&lt;/i&gt; = 0.0732). Post-exercise oral temperatures were significantly higher than pre-exercise temperature values on placebo (&lt;i&gt;p&lt;/i&gt; = 0.0153) and rofecoxib (&lt;i&gt;p&lt;/i&gt; = 0.0424), but not on naproxen (&lt;i&gt;p&lt;/i&gt; = 0.5444). &lt;br&gt;&lt;i&gt;Conclusion.&lt;/i&gt; The results of this study suggest a role for cyclooxygenase-1 (COX-1) in the exercise-induced cortisol and temperature response to exercise.

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