n South African Journal of Sports Medicine - The COL5A1 gene and musculoskeletal soft-tissue injuries : original research article
|Article Title||The COL5A1 gene and musculoskeletal soft-tissue injuries : original research article|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Journal of Sports Medicine|
|Author||Michael Posthumus, Alison V. September, Martin P. Schwellnus and Malcolm Collins|
|Publication Date||Jul 2010|
|Pages||38 - 41|
|Keyword(s)||South African Medical Research Council, The International Olympic Committee Centre of Excellence, Newlands and University of Cape Town|
Background. It has been shown that there is an association between various genetic variants and Achilles tendon injuries as well as anterior cruciate ligament (ACL) ruptures. Among other variants the BstUI restriction fragment length polymorphism (RFLP) within the COL5A1 gene has been shown to be over-represented in asymptomatic participants when compared with those with chronic Achilles tendinopathy, and in asymptomatic female participants when compared with those with ACL ruptures. The male asymptomatic control participants in the ACL study, which were 10 years younger than previously investigated cohorts, had a distinctly different genotype frequency.
Aim. The aim of this study was therefore to determine whether the distribution of the COL5A1 BstUI RFLP in the combined asymptomatic participants without any known history of tendon injuries is age dependent, particularly among males.
Results. When the 265 male asymptomatic participants from all studies were pooled and divided into age-group tertiles, there was a significant linear increase in the CC genotype frequency (p=0.032) among the male age groups, with the youngest group having the lowest frequency (CC genotype frequency, 13%) and the oldest group having the highest (CC genotype frequency, 27%) frequency. There was however a similar CC genotype content in all three female (N=231) age groups (CC genotype frequency, 24 - 27%; p=0.795).
Conclusion. The practical implication is that the selection of asymptomatic groups is of critical importance when future studies of this nature are designed. Future research investigating this genetic variant as a risk factor for soft-tissue injuries should consider these findings when selecting asymptomatic participants.
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