n South African Medical Journal - Adrenal suppression and Cushing's syndrome secondary to ritonavir and budesonide : scientific letters
|Article Title||Adrenal suppression and Cushing's syndrome secondary to ritonavir and budesonide : scientific letters|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Author||D. Gray, P. Roux, M. Carrihill and M. Klein|
|Publication Date||May 2010|
|Pages||296 - 297|
To the Editor : Ritonavir is a protease inhibitor used in combination therapy for advanced HIV infection. In South Africa lopinavir/ritonavir is first-line therapy for children under 3 years of age where there is a history of perinatal exposure to the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine. Ritonavir is a potent inhibitor of hepatic cytochrome P450-CYP3A4 iso-enzyme activity.
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