n South African Medical Journal - Adrenal suppression and Cushing's syndrome secondary to ritonavir and budesonide : scientific letters

Volume 100, Issue 5
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



Ritonavir is a protease inhibitor used in combination therapy for advanced HIV infection. In South Africa lopinavir/ritonavir is first-line therapy for children under 3 years of age where there is a history of perinatal exposure to the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine. Ritonavir is a potent inhibitor of hepatic cytochrome P450-CYP3A4 iso-enzyme activity.

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