n South African Medical Journal - Supporting registration of child-focused clinical trials in Africa : the Child Strategy project : editorials




Child-focused health care workers are compelled to prescribe medicines that lack adequate dosage guidelines for children, as dosing is often derived from data extrapolated from adult studies. Given that the pharmacokinetics and pharmacodynamics of treatments are often unknown for children, and that effectiveness may vary according to age, developmental stage and body size, there is an urgent need to study diagnostic and therapeutic interventions in children to increase the evidence base. A 2005 report of African HIV trial activity identified 77 randomised controlled HIV/AIDS trials prior to 2004. Analysis revealed poor representation of children and adolescents. Currently there is no database dedicated to collating child-focused clinical research for the African continent. Our aim is to summarise evolving efforts for such a resource.


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