n South African Medical Journal - Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus : research
|Article Title||Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus : research|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Groote Schuur Hospital, 2 Groote Schuur Hospital, 3 Groote Schuur Hospital, 4 Groote Schuur Hospital, 5 Groote Schuur Hospital, 6 Groote Schuur Hospital and 7 National Health Laboratory Service|
|Publication Date||Dec 2012|
|Pages||924 - 926|
Sirolimus, a potent inhibitor of B- and T-cell activation, is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus.
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