n South African Medical Journal - South African HIV-1 vaccine candidates - the journey from the bench to clinical trials : forum - reflections
|Article Title||South African HIV-1 vaccine candidates - the journey from the bench to clinical trials : forum - reflections|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 University of Cape Town, 2 University of Cape Town, 3 University of Cape Town, 4 University of Cape Town, 5 University of Cape Town, 6 University of Cape Town, 7 Groote Schuur Hospital, 8 South African Medical Research Council, 9 South African Medical Research Council and 10 University of the Witwatersrand|
|Publication Date||Jun 2012|
|Pages||452 - 455|
Around 2.5 million people become infected with human immunodeficiency virus (HIV) each year. This extraordinary toll in human life and public health worldwide will only be reversed with effective prevention. Vaccination is regarded as the most effective way to prevent infectious disease. However, there are many challenges to overcome before a successful prophylactic HIV vaccine will be available.
We are participating in a global effort to develop and test candidate HIV vaccines. Two candidate prophylactic HIV vaccines that were designed and developed at the University of Cape Town (UCT) entered phase 1 clinical trials in the USA and South Africa in 2009, after a 9-year development period. In addition to the vaccines in clinical trial, there is a pipeline of candidate HIV-1 subtype C vaccines including virus-like particles, novel DNA vaccines, capripoxvirus and Bacillus Calmette-Guérin (BCG)-vectored vaccines. This article describes the history of HIV vaccine research at UCT, and the partnerships that made the project possible.
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