1887

n South African Medical Journal - GST polymorphisms and early-onset coronary artery disease in young South African Indians : research

USD

 

Abstract

Glutathione S-transferases (GSTs) detoxify environmental agents which influence the onset and progression of disease. Dysfunctional detoxification enzymes are responsible for prolonged exposure to reactive molecules and can contribute to endothelial damage, an underlying factor in coronary artery disease (CAD).


We aimed to assess 2 common polymorphic variant isoforms in GSTM1 and GSTP1 of GST in young CAD patients.
All patients (=102) were South Africans of Indian ancestry, a population associated with high CAD risk. A corresponding age-, sex- and race-matched control group (=100) was also recruited. Frequency of the GSTM1 +/0 (v. +/0 and 0/0) and GSTP1 A/G (v. wild-type A/A) genotypes was assessed by differential polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism (PCR-RFLP), respectively.
The GSTM1 0/0 and GSTP1 A/A genotypes occurred at higher frequencies in CAD patients compared with the control group (36% v. 18% and 65% v. 48%, respectively). A significant association with CAD was observed in GSTM1 0/0 (odds ratio (OR)=2.593; 95% confidence interval (CI) 1.353 - 4.971; =0.0043) and GSTP1 A/A OR=0.6011; 95% CI 0.3803 - 0.9503; =0.0377). We found a significant association between smoking and CAD; the presence of either of the respective genotypes together with smoking increased the CAD risk (GSTP1 A relative risk (RR)=1.382; 95% CI 0.958 - 1.994; =0.0987 and GSTM1 null RR=1.725; 95% CI 1.044 - 2.851; =0.0221).
Our findings support the association of genotypes GSTM1 0/0 and GSTP1 A/A and smoking with CAD.

Loading

Article metrics loading...

/content/m_samj/102/7/EJC122908
2012-07-01
2016-12-08
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error