n South African Medical Journal - Profile of cause of death assigned to adults on antiretroviral therapy in Soweto : research
|Article Title||Profile of cause of death assigned to adults on antiretroviral therapy in Soweto : research|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Chris Hani Baragwanath Hospital and 2 University of the Witwatersrand|
|Publication Date||Aug 2012|
|Pages||680 - 682|
This retrospective cohort study describes causes of death in 305 patients (baseline median CD4 count 26/µl) from 2 943 adults on antiretroviral therapy. Acute sepsis (20%), tuberculosis (18%) and Mycobacterium avium complex (MAC) bacteraemia (14%) were the most common causes. Mortality owing to the disease was 66% for MAC bacteraemia and 23% for non-Hodgkin's lymphoma. In 37 patients dying beyond one year on ART, virological failure was present in 11 (30%), and non-HIV-related causes of death occurred in 10. The main causes were acute sepsis (6), tuberculosis (7) and chronic medical conditions (5). Initiating ART at higher CD4 counts should reduce early mortality.
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