n South African Medical Journal - Raising the CD4+ initiation threshold with our eyes wide open : editorial

Volume 103, Issue 11
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



The World Health Organization (WHO) recently advocated raising the CD4+ count threshold for initiating antiretroviral therapy (ART) for HIV-infected adults to 500 cells/µl, from the current 350 cells/µl. Following previous WHO guidance, the current South African (SA) strategy of treating everyone with a CD4+ count <350 cells/µl, and all pregnant women and TB patients, has led to remarkable achievements, cutting mother-to-infant transmission dramatically and increasing life expectancy. The question is: should SA follow the latest WHO recommendation?

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