n South African Medical Journal - Cutaneous adverse drug reactions caused by FDCAs - we need to characterise and manage them urgently - correspondence

Volume 103 Number 11
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



In April 2013, South Africa's Minister of Health launched fixed-dose once-a-day combination antiretrovirals (FDCAs) comprising emtricitabine, efavirenz and tenofovir (Odimune and Tribuss). During the months following the introduction of these drugs, anecdotal reports from clinicians and patients are emerging of cutaneous adverse drug reactions (CADRs) associated with them. We have recently described the clinical characteristics of efavirenz-associated CADRs. Efavirenz is a constituent of the FDCAs, so we have been actively surveying and documenting suspected FDCA-associated CADRs at Groote Schuur Hospital in Cape Town, South Africa.

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