n South African Medical Journal - South African guideline for the management of chronic hepatitis B : 2013 : guideline
|Article Title||South African guideline for the management of chronic hepatitis B : 2013 : guideline|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 University of Cape Town, 2 University of Cape Town, 3 University of Cape Town, 4 South African Gastroenterology Society, 5 South African Gastroenterology Society, 6 South African Gastroenterology Society, 7 Sandton Clinic, 8 University of Pretoria, 9 University of Leuven, Belgium, 10 University of the Witwatersrand, 11 Donald Gordon Medical Centre, 12 Morningside Clinic, 13 Gastroenterology Foundation of South Africa and 14 University of KwaZulu-Natal|
|Publication Date||May 2013|
|Pages||337 - 349|
Hepatitis B remains a significant yet preventable health issue in South Africa. The introduction of the hepatitis B vaccine into the country some 18 years ago has demonstrated benefit, but the exposure to, and prevalence of chronic HBsAg positivity remain unacceptably high. Those with chronic hepatitis B virus infection have an elevated risk of developing cirrhosis with end-stage liver disease and a markedly elevated risk of hepatocellular carcinoma, independent of the presence of cirrhosis.
The challenge in South Africa remains prevention through the universal vaccination coverage of all children and the identification of those with chronic hepatitis B virus infection. Over the last decade our understanding of hepatitis B and its behaviour and natural history in those with chronic infection has significantly improved. This understanding is key to identifying those who warrant further evaluation and therapy. A number of global societies have updated their guidelines in recent years. This document draws on these guidelines and serves to contextualise, for South Africa, practice guidelines for the management of chronic hepatitis B.
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