n South African Medical Journal - Artesunate v. quinine for severe malaria : correspondence
|Article Title||Artesunate v. quinine for severe malaria : correspondence|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 University of KwaZulu-Natal, 2 University of KwaZulu-Natal, 3 Port Shepstone Regional Hospital and 4 Port Shepstone Regional Hospital|
|Publication Date||May 2013|
Severe malaria is a serious and deadly complication of Plasmodium falciparum malaria. We searched the literature to identify the current most efficacious pharmacotherapy for severe malaria. A recent Cochrane meta-analysis compared the efficacy of quinine with artesunate for severe malaria. The primary outcome was all-cause death. The meta-analysis included 8 trials. Artesunate reduced the risk of death both in adults (relative risk (RR) 0.61, 95% confidence interval (CI) 0.50 - 0.75; 1 664 participants, 5 trials) and in children (RR 0.76, 95% CI 0.65 - 0.90; 5 765 participants, 4 trials). In addition, artesunate was less likely to cause hypoglycaemia.
Article metrics loading...