n South African Medical Journal - Diabetes mellitus in HIV-infected patients receiving antiretroviral therapy : research
|Article Title||Diabetes mellitus in HIV-infected patients receiving antiretroviral therapy : research|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Institute for Health Sciences, Botswana, 2 Institute for Health Sciences, Botswana, 3 Institute for Health Sciences, Botswana, 4 Institute for Health Sciences, Botswana, 5 Institute for Health Sciences, Botswana, 6 University of Pennsylvania, USA, 7 University of Pennsylvania, USA, 8 University of Pennsylvania, USA, 9 Botswana/UPenn Partnership, Botswana, 10 Botswana/UPenn Partnership, Botswana, 11 The Children's Hospital of Philadelphia, USA, 12 University of Botswana and 13 University of Botswana|
|Publication Date||Jan 2014|
|Pages||37 - 39|
Background. There is little in the literature on HIV and diabetes mellitus (DM) in sub-Saharan Africa.
Objective. To assess the characteristics of HIV and DM in patients receiving antiretroviral therapy (ART) in Botswana.
Methods. A retrospective case-control study was conducted at 4 sites. Each HIV-infected patient with DM (n=48) was matched with 2 HIV-infected controls (n=108) by age (±2 years) and sex. Primary analysis was conditional logistic regression to estimate univariate odds and 95% confidence intervals (CIs) for each characteristic.
Results. There was no significant association between co-morbid diseases, tuberculosis, hypertension or cancer and risk of diabetes. DM patients were more likely to have higher pre-ART weight (odds ratio (OR) 1.09; 95% CI 1.04 - 1.14). HIV-infected adults >70 kg were significantly more likely to have DM (OR 12.30; 95% CI 1.40 - 107.98). Participants receiving efavirenz (OR 4.58; 95% CI 1.44 - 14.57) or protease inhibitor therapy (OR 20.7; 95% CI 1.79 - 240.02) were more likely to have DM. Neither mean pre-ART CD4 cell count (OR 1.0; 95% CI 0.99 - 1.01) nor pre-ART viral load >100 000 copies/ml (OR 0.71; 95% CI 0.21 - 2.43) were associated with a significant risk of diabetes.
Conclusions. These findings suggest a complex interrelation among traditional host factors and treatment-related metabolic changes in the pathogenesis of DM inpatients receiving ART. Notably, pre-ART weight, particularly if >70 kg, is associated with the diagnosis of diabetes in HIV-infected patients in Botswana.
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