n South African Medical Journal - Orphans, HIVE and HAND : who are the watch-keepers? : editorial
|Article Title||Orphans, HIVE and HAND : who are the watch-keepers? : editorial|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Red Cross War Memorial Children's Hospital, 2 Groote Schuur Hospital, 3 Groote Schuur Hospital, 4 Groote Schuur Hospital, 5 Groote Schuur Hospital, 6 Groote Schuur Hospital and 7 Groote Schuur Hospital|
|Publication Date||Oct 2014|
|Pages||678 - 679|
Since 2004, substantial numbers of South African (SA) children have benefited from antiretroviral treatment. Untreated children are at risk of central nervous system (CNS) sequelae, with prevalence rates of 20 - 60%. HIV-1 invades the developing CNS earlier and with greater severity than in adults, resulting in the condition known as HIV encephalopathy (HIVE). In addition, patients on highly active antiretroviral therapy (HAART) may remain vulnerable to the effects of HIV on the brain, because the CNS may be a reservoir for persistent viral replication. The concept of a 'milder' form of neurocognitive disturbance in HIV-infected children, akin to the adult condition of HAND (HIV-associated neurocognitive disorder), is recognised but has yet to be defined.
Article metrics loading...