n South African Medical Journal - Non-IgE-mediated food allergies : continuing medical education
|Article Title||Non-IgE-mediated food allergies : continuing medical education|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Author||A.J. Terblanche, A.C. Lang, C.L. Gray, E. Goddard, S. Karabus, M. Kriel, A.I. Manjra, S.M. Risenga, D.A. Van der Spuy and M.E. Levin|
|Publication Date||Jan 2015|
Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.
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