n South African Medical Journal - Clinical alert - emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients : in practice
|Article Title||Clinical alert - emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients : in practice|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 Ampath Reference Laboratory, 2 Ampath Reference Laboratory, 3 Ampath Reference Laboratory, 4 Ampath Reference Laboratory, 5 University of Cape Town, 6 University of Fribourg, Switzerland, 7 University of Fribourg, Switzerland and 8 Milpark Hospital|
|Publication Date||May 2016|
|Pages||449 - 450|
The polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.
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