1887

n South African Medical Journal - The impact of HIV infection on the presentation of lung cancer in South Africa : in practice - clinical practice

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Abstract

Despite the very high background prevalence of HIV and smoking-related diseases in sub-Saharan Africa, very little is known about the presentation of lung cancer in HIV-infected individuals.


We prospectively compared HIV-positive (=44) and HIV-negative lung cancer patients (=425) with regard to demographics, cell type, performance status and tumour node metastasis staging at initial presentation.
HIV-positive patients were found to be younger than HIV-negative (mean 54.1 (standard deviation 8.4) years v. 60.5 (10) years, <0.01), more likely to have squamous cell carcinoma (43.2% v. 30.1%, =0.07) and significantly more likely to have a poor Eastern Cooperative Oncology Group (ECOG) performance status of ≥3 (47.7% v. 29.4%, =0.02). In the case of non-small cell-lung cancer, they were also significantly less likely to have early stage lung cancer (0% v. 10.3%, =0.02) compared with HIV-negative patients.
HIV-positive lung cancer patients were younger, significantly more likely to have a poor performance status at presentation and significantly less likely to have early stage lung cancer when compared with HIV-negative patients.

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/content/m_samj/106/7/EJC191237
2016-07-01
2016-12-03
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