n South African Medical Journal - A possible heterozygous advantage in muscular dystrophy : the new millennium
|Article Title||A possible heterozygous advantage in muscular dystrophy : the new millennium|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 University of Oxford, UK and 2 University of Edinburgh, Scotland|
|Publication Date||Jun 2016|
|Pages||65 - 66|
In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.
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