1887

n South African Medical Journal - A possible heterozygous advantage in muscular dystrophy : the new millennium

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Abstract

In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.

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/content/m_samj/106/sup-1/EJC190736
2016-06-01
2016-12-05
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