The Schick reactions of 341 members of a South African hospital staff have been analysed. Schick-positive reactors were immunised with formol toxoid (anatoxine), the sensitivity of the subjects to this vaccine being determined simultaneously with their Schick-reaction (Moloney test). Moloney reactions were more frequent and more severe in Schick-negative subjects. It is, therefore, preferable to postpone the Moloney test until the Schick reaction has been determined. No apparent advantage could be discerned in commencing immunisation with smaller doses of toxoid in severe Moloney Schick-positive reactors, and it is advisable to avoid immunisation with formol toxoid altogether in such adults.
Seven cases of pedunculated thrombi in the first part of the aorta are reported. Six thrombi occluded one or other of the coronary orifices and one thrombus detached itself and blocked the right carotid artery. Syphilitic aortitis accounted for four case, atheroma for two case, and atheroma with underlying syphilitic change for one case. One per cent. of sudden death from cardiac disease is from coronary embolism.