*Read at the S.A. Medical Congress, East London, October 6 to 11, 1947. The application of scientific method and certain basic principles to infant-feeding has simplified and standardised infant nutrition. Reference is made to cow's milk dilutions and the time for introducing dietary supplements. The self-demand feeding schedule is discussed. Feeding principles are tabulated and their application illustrated by means of a simple feeding method. While no attempt has been made to cover the entire field of artificial feeding in this short paper, conditions peculiar to South Africa are stressed.
Laboratory experiments and clinical observations have been descriptionbed which demonstrate that certain vitamins are synthesised by the intestinal microflora ; that sulphonamides, to a varying degree, inhibit the synthesis; and that these drugs do not, in general, prevent the absorption of these vitamins when ingested in the diet. When the less soluble sulphonamides, e.g. sulphaguanidine, are used for periods longer than a week. the Medical Research Council recommends that an ample supply of B vitamins be given simultaneously as a safeguard against avitaminosis. Temporary vitamin deficiencies which may ensue during sulphonamide administration appear to be of little nutritional significance to the vast majority of people treated. With a very few, however, interference with the synthesis and function of such essential metabolites as folic acid may result in the production of severe and often fatal blood dyscrasias. The potential dangers attached to sulphonamide therapy should act as a deterrent against the indiscriminate use of the drugs for trivial complaints.