oa South African Medical Journal - Malignant disease* : a new theory as applied to causation and suggested methods for research and therapy
*This paper was read at the South African Medical Congress at Pretoria, July 1948. The experimental production of carcinogenesis is dependent on a supposed irritation, or metabolite deprivation of a normal cell. It can be prevented by collateral administration with the irritant of vitamins and protein. A chemotherapeutic resistant pathogen can be produced in the same way. Both the above cell types become possessed of the characteristic of autonomy and this characteristic is a permanent one even if the irritant be removed. The suggestion is made that the neoplastic cells and resistant strains revive a dormant faculty for autosynthesis. Anti-biotic attack on these cells fails because of inability of the anti-biotic agent to penetrate through the cell wall. Suggestions are advanced about the nature of this impenetrability and how it may possibly be overcome. The necessity for further research is stressed and it would not be entirely without reason to suggest that such research might begin with the egg and/or the chemotherapeutic resistant pathogen.
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