A case of coarctation of the aorta in a pregnant European woman aged 22 years is descriptionbed and the literature on similar cases is reviewed. Pregnancy and labour are attended by considerable risk in cases of coarctation.
A case of acute hydramnios in a syphilitic mother is presented. The infant was still-born and had duodenojejunal obstruction caused by a mass showing necrosis, granulation tissue formation and lymphocyte and plasma cell infiltration, involving the intestine, the pancreas and adjacent tissues. Spirochaetes were seen in the mass and in the liver. Attention is drawn to the role that may be played by foetal intestinal obstruction in the pathogenesis of hydramnios.
Thirty-six cases of nasal allergy were treated with anthisan; 70%, by adjustment of dosage, were given complete subjective relief so long as they continued to take the original minimal effective controlling dose. This figure is in accord with the results published by Feinberg et al. (1947) using benadryl and neoantergan, and by Calder (1948) using anthisan. There is no evidence that when the drug has been taken for a long time, the effective dose gradually becomes smaller, nor is there any evidence of increasing tolerance. There has been nothing in this series of cases to suggest that the long-continued exhibition of the drug over months produces any ill-effects.
The fungicidal action of various therapeutic substances on two species of Aspergillus causing otomycosis was investigated. It was found that A. Niger was more resistant than A. Nidulans. The most effective fungicides were found to be 1% Methyl green and 50% alcohol or stronger. The results of this investigation indicate that a combination of methyl green and alcohol in the form of a 1% solution of methyl green in 50% alcohol would appear to be the best treatment for this type of otomycosis. It is suggested that a suitable wetting agent be added to facilitate contact between the therapeutic substance and the fungus.