oa South African Medical Journal - Caronamide* : its dosage and use as an enhancing agent in penicillin therapy in children
In spite of the fact that caronamide has been found to have a low order of mild toxic reactions and that its absorption from the gastro-intestinal tract is variable, it has a definite place in penicillin therapy. By reversibly blocking that portion of penicillin excreted by the tubules, it can be used to achieve and maintain higher penicillin levels that could only otherwise be achieved by massive and very frequent penicillin administrations. Given orally to children in a dose of 0.5 to 0.7 gm./Kg./day in 4-hourly aliquots, - it may be used in those cases of infection caused by organisms of relative resistance to penicillin, such as typhoid fever, or in those cases, as abscess formation or subacute bacterial endocarditis, where a high diffusion gradient of penicillin is required to achieve a bactericidal level in the foci of infection.
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