Four cases showing plasma cells in the bone marrow varying from 10% to 54% are presented. Of these, one was a typical case, and two others probable cases of multiple myeloma. The problem of increased numbers of plasma cells in the marrow in non-myelomatous conditions is discussed.
A series of cases of unusual post-traumatic pain response is reviewed. Injury to a recognized nerve or nerve root is a common, but not invariable, cause of such a state, which may be brought about by trivial or severe injury. Motor, sensory and vasomotor effects may arise as secondary phenomena. These are all inconstant and vasomotor effects tend to become less striking in time. There is a tendency to over-reaction to freshly applied painful lesions, even when made at new levels. Therapeutic procedures are a common source of the disorder under discussion. Prolonged pain suffering and complaint can become an important part of the psychological make-up. In seeking a solution to some of the problems of these distressing cases, activity within neural circuits should be stressed rather than the role of isolated conducting pathways. An analogy can be drawn with the primary and secondary disCharging foci of epilepsy.