A study is made of 215 cases or typhoid fever not treated with Chloromycetin, and of 139 cases treated with Chloromycetin. These cases were mostly Natives, and the records were collected from hospitals in various parts of the Union. The case mortality, while lower in the Chloromycetin group than in the control group, was not statistically significantly decreased. The Chloromycetin group spent an average of 28.8 days in hospital while the control group spent an average of 36.5 days. The difference between these figures is statistically significant. The average dose of Chloromycetin in the present series was 14.6 gm. Average days of fever for the Chloromycetin group was 6.3, against 22.0 for the control group. There were more relapses in the Chloromycetin group than in the control group. This difference was not statistically significant. There was a lower rate of complications in the Chloromycetin group than in the controls. This was statistically significant. The question of carriers is discussed. There is neither evidence that Chloromycetin decreases the carrier rate, nor that it cures chronic carriers.
Five cases of central serous retinopathy have been discussed in otherwise healthy young men. The fundus picture in at least four of these has been almost identical. It is suggested that Rift Valley fever apparently is a cause of central serous retinopathy and it may also be a cause of a retinal detachment. The prognosis of this type of case may not be as good as is generally stated.
A case of Rift Valley fever in a human subject is presented. A sequela of retinal changes with loss of central vision, hitherto undescriptionbed in the literature, is reported. The possible mode of infection, on the basis of reported experimental infections, is discussed. The question of a neurotropic strain in human infection is raised.
A task analysis leads to the conclusion that the greatest utility of a retinoscopy rack is in covering the zone of maximum concentration of the refractions. Attempts to cover the whole range of refractions with this type of instrument are made at the expense of accuracy and convenience. The writer's instrument is descriptionbed.