oa South African Medical Journal - Typhoid fever in South Africa : treatment of 215 cases without chloromycetin and 139 with chloromycetin (chloramphenicol)

Volume 25, Issue 50
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



A study is made of 215 cases or typhoid fever not treated with Chloromycetin, and of 139 cases treated with Chloromycetin. These cases were mostly Natives, and the records were collected from hospitals in various parts of the Union. The case mortality, while lower in the Chloromycetin group than in the control group, was not statistically significantly decreased. The Chloromycetin group spent an average of 28.8 days in hospital while the control group spent an average of 36.5 days. The difference between these figures is statistically significant. The average dose of Chloromycetin in the present series was 14.6 gm. Average days of fever for the Chloromycetin group was 6.3, against 22.0 for the control group. There were more relapses in the Chloromycetin group than in the control group. This difference was not statistically significant. There was a lower rate of complications in the Chloromycetin group than in the controls. This was statistically significant. The question of carriers is discussed. There is neither evidence that Chloromycetin decreases the carrier rate, nor that it cures chronic carriers.

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