A review of the new anti-tuberculosis drug, Conteben, is given, and the results of therapy in 10 cases and 10 controls are discussed. It is felt that the drug has a definite effect in pulmonary tuberculosis and that it should be used in earlier cases and for a longer period. The drug is definitely not the cure of tuberculosis. Some toxic effects and their prevention are discussed.
A practical account of the use of potassium in therapy is presented. Disregard for or ignorance of electrolytic imbalances may have been responsible for preventable deaths in certain patients. The basic physiology of potassium blood levels, alkalaemia, and acidaemia is mentioned. The various clinical conditions presenting hypopotassaemia are discussed. Clinical signs and symptoms in hypo- and hyperpotassaemia are noted along with E.C.G. records. Therapeutic applications of potassium chloride are suggested, and chemical solutions specified. A plan for a logical series of biochemical investigations is advised.
Every disease appears as a syndrome of many phenomena; of these, some are aggressive or causative, others defensive, other neutral. Lastly there is a group of phenomena which were originally defensive but which have become exaggerated until they are themselves an offence; this offensive-defensive group may again be subdivided into syndromes where the original defensive character of the phenomenon still transcends its offensive character, and syndromes where the offence of the phenomenon outweighs its defensive value. Various different hypertensive syndromes with known causes are examined and it is shown that the phenomenon of hypertension may play any of these roles. Sometimes it is the cause of the whole disease, sometimes it is defensive against some more malign feature, sometimes it started as defence and gradually became offence, and sometimes it is merely a neutral phenomenon. Before a practitioner decides to attempt the eradication of a disease phenomenon, he should try to decide into which of these groups the feature should be placed. Clearly only offensive features should be eradicated, and then only if their offence outweighs their defensive value. On the whole, medical science has failed to make such a grouping and much unnecessary therapy has resulted.