The use of Pronestyl (procaine Amide Hydrochloride) is discussed in the following types of cases: 1. For allergic conditions. 2. For the relief of itch. 3. For manipulation of painful joints. 4. For the relief of pain due to muscle spasm. 5. For the relief of post-operative pain. PAH is less toxic than Procaine Hydrochloride, and can be given in considerably larger doses. It does not cause central nervous system stimulation, and can therefore be given to the conscious patient without fear of causing convulsions. This (together with its lower toxicity) is, in our opinion, its great advantage over Procaine Hydrochloride. We feel that Procaine Amide Hydrochloride may, in the conscious patient, well replace Procaine Hydrochloride in certain conditions in which hitherto the latter has been used.