oa South African Medical Journal - Blood group substances in antitoxic sera : a potential transfusion hazard
Thirty-six consecutive batches of antitoxin have been investigated for the presence of blood group substances. In- every case an A or A-like substance was present; B substance was not demonstrable.As the injection of group substances results in the formation of immune agglutinins and haemolysins, the above findings explain the mechanism by which the injection of antitoxic sera may produce a similar result. Blood donors, especially of group 0 but also of group B may, after such an injection, be rendered dangerous by the formation of immune anti-A. Every donor should be questioned on this point and a recent history of an injection of antitoxin or of vaccine should debar the use of such a donor for recipients of other groups. The blood of every donor to be used for recipients of other groups should be investigated for the presence of immune forms of agglutinins by the relatively simple techniques now available.
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