A case report is given of a severe allergic reaction following the administration of 60 c.c. dextran intravenously. Some observations on allergenic and antigenic reactions reported in the literature are reviewed, and it is suggested in conclusion that greater caution should be exercised in the use of dextran.
An example of anti-Kell (anti-K) has been found in association with anti-Fya in a White male (Rus) who developed these two antibodies following repeated transfusions. The anti-K was isolated by differential absorption and was found to react with 9ï¿½ 53% of 536 White South Africans and 0.6% of 500 South African Bantu. An example of anti-Cellano (anti-k) has been found in the serum of a Group 0 White female (Eley) who was in urgent need of transfusion. After an extensive search 5 compatible donors were found. Each of them was Kell positive, Cellano negative. From the available literature it appears that this is the third example of anti-Cellano (anti-k) to be reported. The blood relations of the propositus has been examined in 6 blood group systems, viz., A-B-O, Rh, M-N, P, K-k and Fy. No evidence of linkage was detected.
Two fatal cases of an unusual pneumonia are descriptionbed. Following an acute respiratory infection resembling influenza, both these patients developed a long progressive illness characterized by cough, haemoptysis, progressive dyspnoea, cyanosis and terminal asphyxia. Serial X-rays revealed a progressive march of a patchy consolidation commencing in the bases and proceeding towards the apices of the lungs. The direct Coombs test for sensitization of the red blood cells was postive in both cases. Postmortem examination revealed firm fleshy lungs with extensive consolidation. Microscopic examination showed stripping of the lining cells of the alveoli, and abundant hyaline fibrin in the alveoli associated with a mononuclear infiltration but with few neutrophil leucocytes. The aetiology of the condition was not determined but it is suggested that it may have been due to an auto-allergic state initiated by an acute respiratory infection.