oa South African Medical Journal - Immunization against diphtheria : the booster dose

Volume 27, Issue 15
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



A small dose, 0.5 Lf, of dissolved diphtheria toxoid-antitoxin floccules (D.F.), injected intracutaneously, acted as an efficient booster in Schick-negative persons, in pseudoreactors to the Schick and Schick control tests and in those who reacted locally to the D.F injection itself (104 in all). It had no demonstrable boosting effect on the circulating antitoxin of 9 Schick-positive adults, 2 of whom were known to have been immunized in the past.

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