oa South African Medical Journal - ACTH and epileptiform seizures in childhood : a preliminary report

Volume 27, Issue 19
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



1. Two cases of children presenting with frequent petit mal attacks which proved resistant to well-known anti-convulsant drugs, were put on ACTH, 5 mg. 6- hourly, or 10 mg. 3 times per day, gradually reducing the dosage. 2. Improvement was dramatic and maintained, the children remaining well until the present. 3. ACTH is presumed to work on the basis of an autoantigen- antibody reaction in disea ed brain tissue, or else as directly affecting epileptogenic foci, biochemically.

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