oa South African Medical Journal - The effect of Bellergal and Hydergine* on the subjective symptoms : and the peripheral vasomotor reactions in anxiety states

Volume 27, Issue 4
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



*Supplied through the courtesv of Dr. Paul G. Stein, of Sandoz Ltd., Basle, Switzerland. 1. In previous publications we have demonstrated that psychoneurotics can be divided into 2 groups: A. The emotionally tense (acute anxiety) group, characterized plethysmographically by peripheral vasoconstriction; and B. The emotionally less tense (hysteric and neurasthenic) group with peripheral vasodilatation. 2. Hydergine, which is a sympatheticolytic and a vasodilator preparation proves to be a valuable adjunct in the treatment of those cases belonging to group A, i.e. the tense individuals, with a typical plethysmogram. 3. Bellergal is of special value in the treatment of the tense anxiety state (group A), and the clinical improvement is almost invariably accompanied by a relative change from peripheral vasoconstriction to vasodilatation. 4. On the other hand it was found that both bellergal and hydergine have little influence clinically and experimentally in those cases characterized by initial vasodilatation (group B).

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