oa South African Medical Journal - Experimental bilharziasis in animals* : II : correlation of biochemistry (' liver function tests ') and histopathological changes in the liver in early bilharziasis
*This investigation was carried out under the instigation and with the co-operation of the Bilharzia. Natural History Unit of the C.S.I.R. Article I of the series appeared in S. Afr. Med. J., (1952): 26, 1005. 1. Two monkeys were infected with B.bovis and weekly biochemical and histopathological studies were carried out for 25 weeks. 2. The earliest histological change was that of an acute hepatitis, followed by the deposition of numerous ova in the liver. This phase was followed by a giant-cell reaction, the phagocytosis and removal of the majority of ova, and later by the appearance of granulomata. No increase in fibrous tissue was observed. 3. Biochemical changes, especially involving protein metabolism, were observed to coincide with the formation of granulomata; certain of these changes suggest their being due to parenchymal liver damage, while others possibly reflect stimulation of the reticulo-endothelial system.
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