1. A number of cases of typhoid fever showing no response or delayed response to chloramphenicol are presented. 2. Positive isolation from blood may be obtained in spite of chloramphenicol having been given-in case 6 after as much as 8 g. 3. Positive cultures may be obtained in the absence of pyrexia. 4. Isolation of S. typhi from stools and urine has proved disappointing.
1. Experimental and clinical evidence of an additive (and possibly potentiative) synergism between ethyl alcohol and the barbiturate drugs is reviewed. 2. Two cases suggestive of death by this means, are reported. 3. The diagnostic, therapeutic and forensic aspects of this synergism are noted.
1. The chemistry and pharmacology of Laudolissin are descriptionbed. 2. Results of a clinical trial of 62 cases are descriptionbed. 3. It is conduded that it has properties similar to d-tubocurarine with the advantage of a longer action but a disadvantage in its markedly slow onset of action.
Methedrine has been used as a euphoriant in 25 cases of neurosis which were responding insufficiently to other methods of treatment. Eleven patients have improved and all of these were cases in which an element of anxiety or depression was prominent. The dosage is detailed and a few precautions are suggested, but provided reasonable care is taken there appears to be little risk. Methedrine as an agent of abreaction is mentioned but not discussed.