Investigations on the destruction of M. tuberculosis in calabash milk are descriptionbed. It was found that both bovine and human strains of M. tuberculosis were destroyed within 6 days in sour milk in a calabash. Certain lactobacilli were isolated and filtrates of these in glucose broth cultures had an inhibitory effect on the growth of H37Rv and two locally isolated strains of virulent human M. tuberculosis. The pH of the filtrates did not appear to be the inhibitory factor. It is suggested that destruction of tubercle bacilli in souring milk in a calabash might explain further thdifference between the incidence of bovine M. tuberculosis in Native cattle and in Africans in South Africa. The antimicrobial properties of the lactobacilli and yeasts isolated will be investigated further.
*The contents of this paper formed part of the Report rendered to the Brilish Medical Association at the end of the term of office as Insole Research Scholar. 1951-2. (See also Willcox. R. R.: S. Afr. Med. l .. 27, 1036-14 November 1953.-Ed.) 1. Figures are presented which indicate the extent of the problem of non-specific urethritis in Great Britain. The prevalence of the condition follows a similar pattern to that of gonorrhoea. 2. Incubation periods in excess of one week were more frequently noted in patients with non-specific urethritis than in patients with gonorrhoea. 3. In a comparison of age-incidence, marital status and occupation of patients with non-specific urethritis and gonorrhoea, slightly older patients, more married men and more 'white collar' workers were noted in the nonspecific urethritis group. 4. These trends may all be reflections of the same thing, viz. a slightly higher preponderance of non-specific urethritis in married men. 5. The wife or regular consort was nominated more often as the source of infection of non-specific urethritis than of gonorrhoea. 6. There was no evidence that the practice of buccal or anal coitus was commonly responsible for the non-specific urethritis encountered in Great Britain.
Although the series of cases is small, the innocuousness of Laudolissin is proved by the fact that, with the usual care, it has been used with safety in the very 'poor risk' cases, and its prolonged action is most advantageous.
A new synthetic, long-acting curarizing agent, Laudolissin, is descriptionbed. The mode of action, dosage and antidote has been investigated and comparisons made with Flaxedil and d-tubocurarine chloride. The use of other anaesthetic drugs in conjunction with Laudolissin is mentioned.