oa South African Medical Journal - Chlorothiazide - its mode of action and its use in patients with oedema
|Article Title||Chlorothiazide - its mode of action and its use in patients with oedema|
|© Publisher:||Health and Medical Publishing Group (HMPG)|
|Journal||South African Medical Journal|
|Affiliations||1 University of Cape Town and Groote Schuur Hospital, Cape Town|
|Publication Date||Sep 1958|
|Pages||934 - 940|
|Keyword(s)||Chlorothiazide, Mode of action, Oedema, Oral diuretic and Pharmacology|
Short-term studies in 3 patients suggest that chlorothiazide acts by inhibiting the renal tubular reabsorption of chloride and sodium. In this it resembles the organic mercurial diuretics, but there is a rise in urinary pH and a slight increase in the urinary bicarbonate.
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