oa South African Medical Journal - Chlorothiazide - its mode of action and its use in patients with oedema

Volume 32, Issue 38
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



Short-term studies in 3 patients suggest that chlorothiazide acts by inhibiting the renal tubular reabsorption of chloride and sodium. In this it resembles the organic mercurial diuretics, but there is a rise in urinary pH and a slight increase in the urinary bicarbonate.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error