The experimental evidence leading to a human transplantation is reviewed.
The selection and assessment of a donor, and the organization involving a cardiac transplantation unit are briefly descriptionbed.
The pre-operative findings in a patient with intractable heart failure due to massive destruction of the myocardium by ischaemic heart disease are presented.
An account is given of studies of white cell typing which led to the selection, within the limits of present knowledge, of an acceptable donor for heart transplantation.
The conduct of anaesthesia for a patient undergoing cardiac transplantation is descriptionbed.
The first human heart transplant is descriptionbed. The steps leading up to this event are outlined briefly and the operative technique is detailed. The postoperative care of the patient following this successful operation is descriptionbed.